Semantic Information Based Web Service Discovery

Web service discovery is an important part of Web service applications. With the increase of the Web services, there come the problems that we must face to. The technology of traditional Web service discovery is based on the matching foundation of key words by combining WSDL and UDDI standardization. However, it is short of the description of semantic information, which means a low level of intelligence. Thus, it leads to low exactness and completeness. In the light of this issue, the paper draws the concept of semantic information into the research of Web service discovery. Through WordNet, it expands service description, raises semantic information, and makes semantic match possible. The paper puts forward a model based on semantic for Web service discovery, analyzes the function structure and the relationship between component parts of the model, moreover, it describes the work flow of the model. At the same time, the paper enlarges UDDI information and gives a matching algorithm on the similarity calculation through semantic analysis when finding the matched service

Differences in Load Response of Rotator Cuff and Deltoid Muscles in Younger and Older Adults

Shoulder health is essential for the independence of older adults. Many older adults suffer from impairment of shoulder mobility, yet it is unknown how neuromuscular activation patterns in the shoulder change with age. PURPOSE: To analyze electromyographic (EMG) coherence in the delta band (2-5 Hz) - a measure of common drive from the central nervous system related to force output - to the rotator cuff and deltoid muscles in younger and older adults during low, med and high force levels. METHODS: Eighteen younger adults (YA) (11 males, 25 ± 5 years) and 6 older adults (OA) (3 males, 72.7 ± 8 years) were recruited. Intramuscular EMG was recorded from the supraspinatus muscle (SS); surface EMG was recorded from the middle deltoid (MD) and infraspinatus (IS) muscles. Participants performed 30-sec isometric contractions at 30° scaption at 25%, 50%, and 75% of maximal voluntary contraction (MVC) in random order. Z-transformed pooled coherence of three muscle pairs (SS-IS, SS-MD, IS-MD) were compared using a two-way repeated measures ANOVA (group x force) with Bonferroni post-hoc analysis. RESULTS: There was a significant main effect for the group (p = .014) for the SS-MD pair. YA had greater coherence during the 75% MVC (0.29 ± 0.04) than the 25% MVC (0.18 ± 0.02) (p = 0.001). There were no significant differences between contraction intensities for the OA (OA avg. = 0.12 ± 0.02; [0.11 ± .02 – 0.10 ± .05 – 0.15 ± .04]). For the SS-IS pair, there was a main effect of force (p = .011) and a group x force interaction (p = 0.008): YA had greater coherence at 75% MVC (0.31 ± .025) than at 50% MVC (0.14 ± 0.03, p = .009) and 25% MVC (0.17 ± .03, p = .007); whereas, OA showed no significant differences across force levels (25% MVC: 0.10 ± .03, 50% MVC:0.18 ± .03, 75% MVC: 0.14 ± .03]). No significant differences were found in the IS-MD pair across loads in either group (YA avg.= 0.27 ± .04; OA avg. = 0.14 ± .04). CONCLUSION: Overall, younger adults have more common drive to the rotator cuff and deltoid muscles than older adults across all force levels. The lack of response of common drive to changing force levels in older adults reflects age-related changes in neuromuscular control that could affect shoulder joint integrity

Common Drive to Rotator Cuff and Deltoid Muscles During Fatigue in Individuals With and Without Subacromial Pain Syndrome

Individuals with subacromial pain syndrome have greater superior migration of the humeral head during fatiguing contractions. This may be due to lower common drive across the rotator cuff muscles that stabilize the glenohumeral joint. PURPOSE: To identify intermuscular coherence in the delta band (2-5 Hz), which is a measure of common descending drive to muscles associated with force production, across rotator cuff and deltoid muscle in symptomatic and asymptomatic individuals during an isometric fatiguing contraction. METHODS: Twenty symptomatic (12 F, 8 M, 22 ±3 y/o) and 18 asymptomatic (7 F, 11 M, 25 ± 5 y/o) individuals participated in this study. Surface EMG was recorded from the middle deltoid (MD) and infraspinatus (IS). Intramuscular EMG was recorded with fine-wire electrodes in the supraspinatus (SS). Participants performed an isometric fatiguing contraction at 30° scaption at 25% maximal voluntary contraction until endurance limit. Z-transformed pooled coherence of three muscle pairs (SS-IS, SS-MD, IS-MD) were compared with two-way (time x group) repeated measures ANOVAs with Bonferroni post-hoc analysis. RESULTS: Endurance time did not differ between groups (asymptomatic: 5.7 ±1.1 min symptomatic: 6.5±1.4 min). There was a main effect of time (p\u3c0.01) and a significant group x time interaction for SS-IS coherence (p\u3c0.05). SS-IS coherence did not differ between groups during the initial fatigue phases (avg.=0.16±0.02). SS-IS coherence increased with fatigue in the asymptomatic group (initial = 0.16 ± 0.03, final = 0.22 ± 0.03), but not in the symptomatic group (avg. = 0.15±0.03). There was also a main effect of time on SS-MD coherence (p\u3c0.05), which increased with fatigue in both the asymptomatic (initial=0.11±0.02, final=0.18±0.04) and the symptomatic (initial=0.11±0.01, final=0.13±0.02) groups. IS-MD coherence did not change with fatigue in either group (avg.= 0.22 ± 0.03).CONCLUSION: During neuromuscular fatigue, common drive to the SS and MD increased in individuals with and without subacromial pain. However, common drive to the rotator cuff muscles (SS and IS) only increased with fatigue in the asymptomatic group. Therefore, lower common drive to the SS and IS may be a cause of the decrease in joint stability and narrowing of subacromial space in patients with subacromial pain syndrome

Research on the Supply Chain Partnership Relations with Association Rule Analysis

Due to that many fuzzy and uncertain association relations represented by some phenomenon in the process of enterprises cooperation in supply chain, data mining method was try out in this paper. At first, concept and deducing procedure was introduced, and then 300 samples from a survey was pretreatment, in succession cooperation relations of enterprises in supply chain was studied combined with association analysis method. Some acceptable conclusions were obtained, which can explain the relations between modality and measures of cooperation of enterprises reasonably

Intermuscular Coherence of Rotator Cuff and Deltoid Muscles Varies with Force Output

Maintaining glenohumeral joint stability requires coordination of the rotator cuff and deltoid muscles. Load changing may alter the neuromuscular control patterns between these two muscle groups. PURPOSE: To identify intermuscular EMG coherence patterns between the rotator cuff and deltoid muscles at different force levels. METHODS: Surface EMG electrodes were used to record activity from the anterior deltoid (AD), middle deltoid (MD), and infraspinatus (IS) muscles of the dominant shoulder in 7 healthy individuals (mean age ± SD = 19±1, 6 females, 1 male). An intramuscular fine-wire EMG electrode was inserted into supraspinatus (SS). Participants performed 30s contractions of isometric shoulder abduction in the scapular plane at 30° at 25% (low-load), 50% (medium-load) and 75% (high-load) of maximum voluntary contraction with visual feedback of the force output. EMG amplitudes and coherence of each muscle pair in the common drive (0-5 Hz), physiological force tremor (5-12 Hz), beta (15-35 Hz), low-gamma (35-60 Hz) and high-gamma (60-100 Hz) bands were compared across the 3 force levels. RESULTS: EMG amplitudes of all muscles increased as force level increased (all pCONCLUSION: Increasing force output led to decreased coherence within the rotator cuff muscles and between supraspinatus and the deltoid muscles, but increased coherence between infraspinatus and the deltoid muscles. This likely serves as a protective mechanism against superior humeral head migration

IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease

Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and PrP neurotoxicity in vitro, it remained unknown whether IVIG could reduce amyloid plaque pathology in vivo and be used to effectively treat animals with prion diseases. In this study, we used Gerstmann-Sträussler-Scheinker (GSS)-Tg (PrP-A116V) transgenic mice to test IVIG efficacy since amyloid plaque formation played an important role in GSS pathogenesis. Here, we provided strong evidence that demonstrates how IVIG could significantly delay disease onset, elongate survival, and improve clinical phenotype in Tg (PrP-A116V) mice. Additionally, in treated animals, IVIG could markedly inhibit PrP amyloid plaque formation and attenuate neuronal apoptosis at the age of 120 days in mice. Our results indicate that IVIG may be a potential, effective therapeutic treatment for GSS and other prion diseases

A robot-aided visuomotor wrist training induces gains in proprioceptive and movement accuracy in the contralateral wrist

Proprioceptive training is a neurorehabilitation approach known to improve proprioceptive acuity and motor performance of a joint/limb system. Here, we examined if such learning transfers to the contralateral joints. Using a robotic exoskeleton, 15 healthy, right-handed adults (18-35 years) trained a visuomotor task that required making increasingly small wrist movements challenging proprioceptive function. Wrist position sense just-noticeable-difference thresholds (JND) and spatial movement accuracy error (MAE) in a wrist-pointing task that was not trained were assessed before and immediately as well as 24 h after training. The main results are: first, training reduced JND thresholds (- 27%) and MAE (- 33%) in the trained right wrist. Sensory and motor gains were observable 24 h after training. Second, in the untrained left wrist, mean JND significantly decreased (- 32%) at posttest. However, at retention the effect was no longer significant. Third, motor error at the untrained wrist declined slowly. Gains were not significant at posttest, but MAE was significantly reduced (- 27%) at retention. This study provides first evidence that proprioceptive-focused visuomotor training can induce proprioceptive and motor gains not only in the trained joint but also in the contralateral, homologous joint. We discuss the possible neurophysiological mechanism behind such sensorimotor transfer and its implications for neurorehabilitation

Charting the Unexplored RNA-binding Protein Atlas of the Human Genome

poster abstractDetecting protein-RNA interactions is challenging–both experimentally and computationally– because RNAs are large in number, diverse in cellular location and function, and flexible in structure. As a result, many RNA-binding proteins (RBPs) remain to be identified and characterized. Recently, we developed a bioinformatics tool called SPOT-Seq that integrates template-based structure prediction with RNA-binding affinity prediction to predict RBPs. Application of SPOT-Seq to human genome leads to doubling of RBPs from 2115 to 4296. Half of novel (>2000) RBPs are poorly or not annotated. The other half possesses Gene Ontology leaf IDs that are associated with known RBPs. In particular, we identified 36 novel RBPs in cancer, cardiovascular, diabetes and neurodegenerative pathways and 26 novel RBPs associated with disease-causing SNPs. Half of these disease-associating, predicted novel RBPs are annotated to interact with known RBPs. Accuracy of predicted novel RBPs is further validated by same confirmation rate of novel and annotated RBPs in human proteome microarrays experiments. The large number of predicted novel RBPs and their abundance in disease pathways and disease-causing SNPs are useful for hypothesis generation. These predicted novel human RBPs (>2000) with confidence level and their predicted complex structures with RNA can be downloaded from http://sparks.informatics.iupui.edu ([email protected]